CHLORQUINALDOL (5,7-DICHLORO-2-METHYL-8-HYDROXYQUINOLINE)

CHLORQUINALDOL

PRODUCT IDENTIFICATION

CAS NO.

72-80-0

CHLORQUINALDOL

EINECS NO. 200-789-3

FORMULA C₁₀H₇Cl₂NO

MOL WT. 228.08

H.S. CODE

TOXICITY

SYNONYMS 5,7-Dichloro-2-methyl-8-hydroxyquinoline;

5,7-Dichloro-8-hydroxyquinaldine; Hydroxydichloroquinaldine; 5,7-dichloro-8-quinaldinol;

CLASSIFICATION

8-QUINOLINOLS / ANTISEPTICS /

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE yellow to brown crystalline powder

MELTING POINT 108 - 112 C (Decomposes)

BOILING POINT

SPECIFIC GRAVITY

SOLUBILITY IN WATER

VAPOR DENSITY

REFRACTIVE INDEX

NFPA RATINGS

Health: 1; Flammability: 0; Reactivity: 0

AUTOIGNITION

FLASH POINT

STABILITY Stable under normal conditions

GENERAL DESCRIPTION OF QUINOLINE & APPLICATIONS

Quinoline, hygroscopic, yellowish oily liquid, is an aromatic nitrogen compound characterized by a double-ring structure contains a benzene and a pyridine. (Pyridine is a ring structure compound of five carbon atoms with a nitrogen atom). These two rings are fused at two adjacent carbon atoms. Quinoline itself is the simplest member of the quinoline. It can be prepared by the distillation of coal tar or by synthesis from aniline. It is soluble in water as well as in alcohol, ether, and carbon disulfide. Isoquinoline differs from quinoline in nitrogen position. Quinoline family compounds are widely used as a parent compound to make drugs (especially anti-malarial medicines), fungicides, biocides, alkaloids, dyes, rubber chemicals and flavoring agents. They have antiseptic, antipyretic, and antiperiodic properties. They are also used as catalyst, corrosion inhibitor, preservative, and as solvent for resins and terpenes. They are used in transition-metal complex catalyst chemistry for uniform polymerization and luminescence chemistry.

Chlorquinaldol, 5,7-dichloro-2-methyl-8-hydroxyquinoline, has antibacterial, antifungal and amoebicidal activity with antieczematic and antipruritic properties; used topically in the treatment of cutaneous and vaginal infections. It is a similar agent to clioquinol.

Clioquinol is one of the halogenated 8-quinolinols which are antibacterial, intestinal antiamebic, and vaginal trichomonacide agents. They are derived from 8-hydroxyquinoline, an antiseptic agent with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. Clioquinol, iodochlorohydroxyquinoline, is an antifungal with antieczematic and antipruritic properties. Clioquinol topical preparations are used to treat skin infections. It was administered orally in the treatment of amebic dysentery. The oral preparation is banned worldwide due to associated subacute myelo-optic neuropathy.

SALES SPECIFICATION

APPEARANCE

yellow to brown crystalline powder

CONTENT

99.0% min

MELTING POINT

108 - 112 C

TRANSPORTATION

PACKING

25kgs in fiber drum

HAZARD CLASS 6.1 (Packing Group: III)

UN NO. 2811

OTHER INFORMATION

Hazard Symbols: XN, Risk Phrases:22-36/37/38, Safety Phrases: 26-36

PRICE INFORMATION