| CAS
NO. |
66-81-9, 21059-09-6 |
|
| EINECS
NO. |
200-636-0 |
| FORMULA |
C15H23NO4 |
| MOL
WT. |
281.35 |
|
H.S.
CODE
|
|
|
TOXICITY
|
|
| SYNONYMS |
Actidione; neocycloheximide; |
|
[1S-[1alpha(S),3alpha,5beta]]-4-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]-2,
6- Piperidinedione;
3-(2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)glutarimide;
3-((R)-2-((1S,3S,5S)-3,5- dimethyl-2- oxocyclohexyl)-2-hydroxyethyl)glutarimide;
4-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2- hydroxyethyl]-2,6- piperidinedione; |
|
SMILES |
|
|
CLASSIFICATION
|
|
|
PHYSICAL
AND CHEMICAL PROPERTIES
|
| PHYSICAL
STATE |
white to
yellowish crystalline powder |
| MELTING
POINT |
119
- 121 C
|
| BOILING
POINT |
|
| SPECIFIC
GRAVITY |
|
| SOLUBILITY
IN WATER |
2-5 g/100ml
(soluble in alcohol,
chloroform, ether, acetone) |
| pH |
|
| VAPOR
DENSITY |
|
| AUTOIGNITION |
|
| NFPA
RATINGS |
|
|
REFRACTIVE
INDEX
|
|
| FLASH
POINT |
|
| STABILITY |
Stable
under ordinary conditions. |
|
GENERAL
DESCRIPTION & APPLICATIONS
|
Cycloheximide (also known as actidione) is used as an selective antibiotic. It
inhibits the protein synthesis (DNA-dependent RNA) of saprobic fungi eukaryotes.
by binding with the 80S ribosome, while inactive against dermatophytes and
systemic fungi. But it is not active against prokaryotes. it is used in the
selection of wild type genes. It is used as a plant growth regulator to
stimulate ethylene production. It is used as a rodenticide and other animal
pesticide. It is used as a media to detect to unwanted bacteria by suppressing
yeasts and molds in beer fermentation. Some products such as nisin have this
effective function as a preservative for food and beverage. But cycloheximide is
highly toxic is not suitable for human use as a therapeutic antibiotic.
Agricultural application also is decreasing due to the health risks. It is used
as an agent effective against psoriasis.
| Antipsoriatic |
CAS
RN
|
| Acitretin |
55079-83-9 |
| Isoacitretin |
69427-46-9 |
| Anthralin |
480-22-8 |
| Azaribine |
2169-64-4 |
| Calcipotriene |
112965-21-6 |
| Calcitriol |
32222-06-3 |
| Cedefingol |
35301-24-7 |
| Cycloheximide |
66-81-9 |
| Cyclosporine |
59865-13-3 |
| Etretinate |
54350-48-0 |
|
Fumaric acid
|
110-17-8
|
| Hydroxyurea |
127-07-1 |
| Liarozole fumarate |
145858-52-2 |
| Lonapalene |
91431-42-4 |
| Methotrexate |
59-05-2 |
| Methoxsalen |
298-81-7 |
| Moxilubant maleate |
147398-01-4 |
| Nimidane |
50435-25-1 |
| Peldesine
|
133432-71-0 |
| Safingol hydrochloride |
139755-79-6 |
| Safingol |
15639-50-6 |
| Tacalcitol |
57333-96-7 |
| Tazarotene |
118292-40-3 |
| Tepoxalin |
103475-41-8 |
| Trioxsalen |
3902-71-4 |
| 5-Methoxypsoralen |
484-20-8 |
| 6-Thioguanine |
154-42-7 |
|
| SALES
SPECIFICATION |
|
APPEARANCE
|
white to
yellowish crystalline powder |
|
ASSAY
|
95.0
% min
|
|
LOSS
ON DRYING
|
0.5%
max
|
|
MELTING
POINT
|
119
- 121 C
|
| TRANSPORTATION |
| PACKING |
|
| HAZARD
CLASS |
|
| UN
NO. |
|
| OTHER
INFORMATION |
| Hazard
Symbols: T+ N, Risk Phrases: 28-51/53-61-68, Safety Phrases: 45-53-61 |
| PRICES |
|
