|
|
|
| DIHYDROARTEMISININ | ||
|
PRODUCT IDENTIFICATION |
||
| CAS NO. | 81496-82-4 |
|
| EINECS NO. | ||
| FORMULA | C15H24O5 | |
| MOL WT. | 284.35 | |
|
H.S. CODE |
||
|
TOXICITY |
||
| SYNONYMS | Dihydro-Qinghaosu; | |
| (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-3,6,9-trimethyl-3,12-epoxy- 12H-pyrano[4,3-j]- 1,2-benzodioxepin-10-ol; | ||
| SOURCE |
|
|
|
CLASSIFICATION |
||
|
PHYSICAL AND CHEMICAL PROPERTIES |
||
| PHYSICAL STATE | White crystalline powder | |
| MELTING POINT | 140 C | |
| BOILING POINT | ||
| SPECIFIC GRAVITY | ||
| SOLUBILITY IN WATER | Insoluble | |
| pH | ||
| VAPOR DENSITY |
| |
|
AUTOIGNITION |
| |
|
NFPA RATINGS |
||
|
REFRACTIVE INDEX |
||
| FLASH POINT |
| |
| STABILITY | Stable under ordinary conditions. | |
|
GENERAL DESCRIPTION & APPLICATIONS |
||
| artemisinin, isolated from Chinese-Vietnamese plant Artemisia annua L., locally called "qing hao", is a new class anti-malarial drugs. It is a white crystalline powder with a bitter taste; practically insoluble in water, soluble in chloroform, acetone, and alcohols. Its chemical designation is (3R,5aS,6R,8aS,9R,12S,12aR)- octahydro-3,6,9-trimethyl-3,12-epoxy- 12H-pyrano[4.3-j]-1,2-benzodioxepin-10(3H)-one. Malaria is one of leading re-emerging infectious disease due to murative malarial parasite developed resistance to chloroquine. Sulfadoxine-pyrimethamine is an alternative can be used in the treatment of the disease resistant to chloroquine, but resistance to sulfadoxine-pyrimethamine has been reported also in some areas. Artemisinin is an alternative used in areas where the disease has become highly resistant to sulfadoxine-pyrimethamine. Dihydroartemisinin, its methyl ether (artemether), its ehyl ether (its (arteether) and its hemisuccinate ester (artesunate) are known as more effective than its parent material - artemisinin. Artemisinin is a peroxide-bridged sesquiterpene lactone compound which has no N atom, unlike quinine class anti-malarial drugs. The characteristic peroxide lactone structure is indispensable for anti-malarial activity. The term of artemotil refers to the pure beta-epimer of arteether. | ||
| SALES SPECIFICATION | ||
|
APPEARANCE |
White crystalline powder | |
|
IDENTIFICATION |
Complies |
|
|
ASSAY (HPLC) |
98.0% min | |
|
LOSS ON DRYING |
0.5% max |
|
| HEAVY METALS |
10ppm max |
|
|
SULFATED ASH |
0.1% max |
|
|
FREE Cl |
0.02% max |
|
| TRANSPORTATION | ||
| PACKING |
| |
| HAZARD CLASS | ||
| UN NO. | ||
| PRICE | ||
|
|
||
|
|
|
|
|
