ENROFLOXACIN

PRODUCT IDENTIFICATION

CAS NO. 93106-60-6

ENROFLOXACIN

EINECS NO.  
FORMULA C19H22FN3O3
MOL WT. 359.40

H.S. CODE

 

TOXICITY

 
SYNONYMS Baytril;
1-Cyclo-propyl-7-(4-ethyl-1-piperazinyl)-6- fluoro-1,4-dihydro-4-oxo-3-quinolone carboxylic acid;
SMILES

 

CLASSIFICATION

FLUOROQUINOLONES /

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to pale yellow crystalline powder
MELTING POINT 219 - 233 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER Slightly soluble
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS  

REFRACTIVE INDEX

 
FLASH POINT

 

STABILITY

Stable under ordinary conditions

GENERAL DESCRIPTION & APPLICATIONS

Enrofloxacin is a veterinary quinolone antibiotic with actions and uses similar to ciprofloxacin, a counterpart for human use; ethyl group is attached to the piperazine ring. Quinolone antibiotic acts by inhibiting the bacterial enzymes DNA gyrase. It has a broad-spectrum antibacterial activity against for both gram negative and positive bacteria and has post-antibiotic effect to enhance epidermal repair by reducing inflammation. It is a white to pale yellow crystalline powder; slightly soluble in water; melting point 219 - 233 C. Chemical designation is 1-cyclo-propyl-7-(4-ethyl-1- piperazinyl)- 6- fluoro-1,4- dihydro-4- oxo-3-quinolone carboxylic acid.

 

Fluoroquinolones belong to a group of synthetic antibiotics that are derived from basic structure of nalidixic acid and have substituents at N-1, C-5, C-7, position 8 and a fluorine atom at position 6. There are also polycyclic derivatives. Quinolone antibiotics have a ketone at position 4 and a carboxylic group at position 3. Fluoroquinolones inhibit the bacterial DNA gyrase or the topoisomerase IV enzyme, resulting the inhibition of DNA replication and transcription. Fluorine at position 6 enhances gyrase inhibition and cell penetration. Piperaziny substituents provide activity against Gram-negative bacteria and pyrrolidinyl moiety is active against Gram-positive cocci. They improve water solubility needed oral application. The function substituted at position 8 IS to control anaerobe activity.
 

Fluoroquinolone

Substituent

Substituted at N-1

 

Norfloxacin

Ethyl

Enoxacin

Ethyl

Lomefloxacin

Ethyl

Fleroxacin

Fluoro ethyl

Difloxacin

Fluorophenyl

Temafloxacin

Difluorophenyl

Trovafloxacin

Difluorophenyl

Amifloxacin

Methyl amino

Ciprofloxacin

Cyclopropyl

Grepafloxacin

Cyclopropyl

Alumofloxacin

Cyclopropyl

Gemifloxacin

Cyclopropyl

Moxifloxacin

Cyclopropyl

Ecenofloxacin

Cyclopropyl

Balofloxacin

Cyclopropyl

Substituted at C-5

 

Sparfloxacin

Amine

Grepafloxacin

Methyl

Substituted at C-7

 

Trovafloxacin

Bicyclic

Moxifloxacin

Bicyclic

Danafloxacin

Bicyclic

Garenoxacin

Bicyclic

Ciprofloxacin

Piperazinyl

Lomefloxacin

Piperazinyl

Norfloxacin

Piperazinyl

Fleroxacin

Piperazinyl

Ofloxacin

Piperazinyl

Sparfloxacin

Piperazinyl

Grepafloxacin

Piperazinyl

Gatafloxacin

Piperazinyl

Levofloxacin

Piperazinyl

Clinafloxacin

Pyrrolidinyl

Nadifloxacin

Pyrrolidinyl

Sitafloxacin

Pyrrolidinyl

Irloxacin

Pyrryl

Balofloxacin

Piperidinyl

Substituted at position 8

 

Sparfloxacin

F

Lomefloxacin

F

Fleroxacin

F

Ciprofloxacin

CH2

Temafloxacin

CH2

Pefloxacin

CH2

Norfloxacin

CH2

Grepafloxacin

CH2

Clinafloxacin

Cl

Sitafloxacin

Cl

Enoxacin

N

Tosufloxacin

N

Gemifloxacin

N

Trovafloxacin

N

Ecenofloxacin

N

Alatrofloxacin

N

Gatifloxacin

Methoxy

Pazufloxacin

Methoxy

Balofloxacin

Methoxy

Moxifloxacin

Methoxy

Garenoxacin

Methoxy

Tricyclic derivatives

 

Abufloxacin

 

Droxacin

 

Flumequine

 

Levofloxacin

 

Marbofloxacin

 

Miloxacin

 

Ofloxacin

 

Oxolinic acid

 

Pazufloxacin

 

Prulifloxacin

 

Rufloxacin

 

Verbafloxacin

 

SALES SPECIFICATION

APPEARANCE

white to pale yellow crystalline powder

ASSAY

98.0 - 102.0%

MELTING POINT

219 - 233 C

HEAVY METALS

20ppm max

LOSS ON DRYING

1.0% max

FLUORIDE

4.5% max

TRANSPORTATION
PACKING
25kgs in drum
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: , Risk Phrases: , Safety Phrases: 22-24/25
PRICE INFORMATION
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