FELODIPINE

FELODIPINE
PRODUCT IDENTIFICATION
CAS NO.	72509-76-3, 86189-69-7
EINECS NO.
FORMULA	C₁₈H₁₉Cl₂NO₄
MOL WT.	384.26
H.S. CODE
TOXICITY
SYNONYMS	Plendil;
4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester; (±)-Ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5- pyridinedicarboxylate;
CLASSIFICATION
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	white crystalline powder
MELTING POINT	142 - 145 C
BOILING POINT
SPECIFIC GRAVITY
SOLUBILITY IN WATER	Insoluble
pH
VAPOR DENSITY
AUTOIGNITION
NFPA RATINGS	`Health: 1; Flammability: 0; Reactivity: 0`
REFRACTIVE INDEX
FLASH POINT
STABILITY	stable under ordinary conditions.
APPLICATIONS
Calcium ions are needed for electrical activity for the contraction of cardiac and smooth muscle and conduction of nerve cell. Calcium channel blocker is a drug which inhibits the entry of excess calcium into cells and/or prevents form the mobilization of calcium from intracellular stores, resulting in relaxation of blood vessel walls and cardiac muscle for blood to flow more freely, lowering blood pressure thereby reducing oxygen demand in the heart and relieving anginal pain. It is used in the treatment of angina, cardiac arrhythmias, and hypertension. Some major calcium channel blockers upon chemical structure are: Dihydropyridine calcium channel blockers ; Amlodipine, Lacidipine, Lercanidipine, Nicardipine, Nifedipine, Nisoldipine, Nitrendipine, Nimodipine. Phenylalkylamine calcium channel blockers ; Gallopamil, Verapamil Benzothiazepine calcium channel blockers; Diltiazem Diarylaminopropylamine ethers; Bepridil, Mibefradil Felodipine is a medication belongs to dihydropyridine calcium channel blockers. Chemical designation is (±)-Ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5- pyridinedicarboxylate. It is a yellowish crystalline powder; melting point 142 - 145 C; insoluble in water; soluble in chloroform, alcohol.
SALES SPECIFICATION ( USP25)
APPEARANCE	yellowish crystalline powder
ASSAY	98.0 - 102.0%
IDENTIFICATION	pass
RESIDUE ON IGNITION	0.1% max
HEAVY METALS	20ppm max
MELTING POINT	142 - 145 C
TOTAL IMPURITY	1.5% max (Individual impurity: 1.0% max)
TRANSPORTATION
PACKING
HAZARD CLASS
UN NO.
OTHER INFORMATION
`Hazard Symbols: XN, Risk Phrases: 22/36/37/38, Safety Phrases: 24/25` PRICE INFORMATION