FLUPHENAZINE

FLUPHENAZINE
PRODUCT IDENTIFICATION
CAS NO.	69-23-8 (Base) 146-56-5 (HCl) 5002-47-1(Decanoate)
EINECS NO.	200-702-9, 205-674-1, 225-672-4
FORMULA	C₂₂H₂₆F₃N₃OS
MOL WT.	437.52
H.S. CODE
TOXICITY
SYNONYMS	Modecate; Permitil; Omca; Prolixine; Sevinol; Prolixin;
4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-1-Piperazineethanol; 4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]-1-Piperazineethanol; Elinol; Fluorfenazine; Fluorphenazine; Pacinol; Siqualine; Siqualon; Tensofin; Triflumethazine; Valamina; Vespazine; Anatensol; 10-(3-(2-Hydroxyethyl)piperazinopropyl)-2- (trifluoromethyl) Phenothiazine; Moditen; 4-(3-(2-Trifluoromethyl-10- phenothiazyl)- propyl)-1-piperazineethanol; 4-[3-[2-(Trifluoromethyl)- 10H-phenothiazin-10-yl] propyl]-1- piperazineethanol; 2-(4-(3-[2-(Trifluoromethyl)-10H- phenothiazin-10- yl]propyl)-1-piperazinyl) ethanol;
SMILES
CLASSIFICATION
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	white to off-white crystalline powder
MELTING POINT
BOILING POINT
SPECIFIC GRAVITY
SOLUBILITY IN WATER
pH
VAPOR DENSITY
REFRACTIVE INDEX
NFPA RATINGS
AUTOIGNITION
FLASH POINT
STABILITY	Stable under normal conditions
APPLICATIONS
Fluphenazine is a short-acting piperazine phenothiazine antipsychotic drug which exhibits a more propensity for producing extrapyramidal reactions than the group of phenothiazine antipsychotic drugs, and used via injection sometimes. It may occur less hypertension but less potentiating effect on CNS depressants, anesthetics sedating than the group of phenothiazine antipsychotic drugs.
SALES SPECIFICATION (BP/USP/CP)
FLUPHENAZINE DIHYDROCHLORIDE
APPEARANCE	white crystalline powder
IDENTIFICATION	pass
ASSAY	98.5 - 101.5%
LOSS ON DRYING	1.0% max
SULFATED ASH	0.1% max
INDIVIDUAL IMPURITY	0.2% max (total 0.5% max)
HEAVY METALS	10ppm max
FLUPHENAZINE DECANOATE
APPEARANCE	pale yellow oily liquid or solid
IDENTIFICATION	complies TEST A (IR-spectrum) TEST B (thin-layer chromatography)
ASSAY	98.5 - 101.5%
LOSS ON DRYING	1.0% max
SULFATED ASH	0.1% max
HEAVY METALS	20ppm max
TRANSPORTATION
PACKING	small and bulk
HAZARD CLASS	6.1 (Packing Group: III)
UN NO.	2811
OTHER INFORMATION
`Hazard Symbols: XI, Risk Phrases:`20/21/22`, Safety Phrases: 36`SHELF LIFE : 4 Years
GENERAL DESCRIPTION OF ANTIPSYCHOTIC AGENTS
The term antipsychotic refers to a group of drugs effective in the treatment of psychosis including schizophrenic, paranoid, schizoaffective, bipolar disorder, and other psychotic disorders. Traditional antipsychotic agents have phenothiazine structure chemically. Phenothiazinene drugs are adrenergic blocking agents. Their pharmacologic actions including central nervous system depression, prolongation and potentiation of the effects of narcotic and hypnotic drugs, hypotensive activity, and antispasmodic, antihistaminic, and antiemetic activity. Other chemcial structures for antipsychotic drugs are diverse, they include thioxanthene, butyrophenone, dibenzoxazepine, dihydroindolone, benzisoxazole, and diphenylbutylpiperidine. Antipsychotic agents bind to dopamine, histamine, muscarinic cholinergic, a-adrenergic, and serotonin receptors. Blockade of dopaminergic transmission in various areas is known to be responsible for their major effects such as not only antipsychotic action by blockade in the mesolimbic and mesocortical areas and and antiemetic effects by blockade in the chemoreceptor trigger zone of the medulla but also extrapyramidal side effects (dystonia, akathisia, parkinsonism, and tardive dyskinesia) by blockade in the basal ganglia and sedation and autonomic side effects (orthostatic hypotension, blurred vision, dry mouth, nasal congestion, and constipation) by blockade of histamine, cholinergic, and adrenergic receptors. The antipsychotic agents may be divided by chemical group and and the decreased propensity of extrapyramidal side effects into two main groups and a new class which is being processed. Typical Antipsychotic Chlorpromazine (CAS #: 50-53-3, Phenothiazine with aliphatic side chain) Promazine (CAS #: 58-40-2, Phenothiazine with aliphatic side chain) Triflupromazine (CAS #: 146-54-3, Phenothiazine with aliphatic side chain) Methotrimeprazine (CAS #: 60-99-1, Phenothiazine with aliphatic side chain) Thioridazine (CAS #: 50-52-2, Phenothiazine with piperidine side chain) Mesoridazine (CAS #: 5588-33-0, Phenothiazine with piperidine side chain) Acetophenazine (CAS #:2751-68-0, Phenothiazine with piperazine side chain) Perphenazine (CAS #: 58-39-9, Phenothiazine with piperazine side chain) Trifluoperazine (CAS #: 117-89-5, Phenothiazine with piperazine side chain) Fluphenazine (CAS #: 69-23-8, Phenothiazine with piperazine side chain) Prochlorperazine (CAS #: 58-38-8, Phenothiazine with piperazine side chain) Chlorprothixene (CAS #: 113-59-7 Thioxanthene) Thiothixene (CAS #: 22189-31-7, Thioxanthene) Haloperidol (CAS #: 52-86-8, Phenylbutylpiperadine) Pimozide (CAS #: 2062-78-4, Phenylbutylpiperadine) Loxapine (CAS #: 1977-10-2, Dibenzoxazepine) Molindone (CAS #: 7416-34-4, Dihydroindolone) Atypical Antipsychotics Clozapine (CAS #: 5786-21-0, Dibenzoxazepine) Olanzapine (CAS #: 132539-06-1, Dibenzoxazepine) Quetiapine (CAS #: 111974-69-7, Dibenzoxazepine) Ziprasidone (CAS #: 138982-67-9, Benzisoxazole) Risperidone (CAS #: 106266-06-2, Benzisoxazole) Partial dopamine agonists Aripiprazole (CAS #: 129722-12-9, Dihydroquinolinone) Lithium carbonate
PRICE INFORMATION