IRBESARTAN

PRODUCT IDENTIFICATION

CAS NO. 138402-11-6

IRBESARTAN

EINECS NO.  
FORMULA C25H28N6O
MOL WT. 428.54

H.S. CODE

 

TOXICITY

 

SYNONYMS Avapro;
2-Butyl-3-[[ 29-( 1H-tetrazol-5-yl) [1, 19-biphenyl]-4-yl] methyl]1,3- diazaspiro[4,4] non-1-en-4-one; 2-Butyl-3-(p-(o-1H-tetrazol-5-ylphenyl)benzyl)-1,3-diazaspiro(4.4)non-1-en-4-one;
SMILES

 

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white crystalline powder
MELTING POINT 165 - 167 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER Soluble
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

 

REFRACTIVE INDEX

 
FLASH POINT

 

STABILITY

Stable under ordinary conditions

GENERAL DESCRIPTION & APPLICATIONS

Angiotensin is a polypeptide vasopressor hormone formed by the catalytic action of renin which is released mainly by the kidneys in response to low blood volume or low sodium content in the body. The juxtaglomerular cells release renin, when juxtaglomerular apparatus decreases in the kidneys. Renin (called angiotensinogenase, EC 3.4.23.15) is an enzyme of the hydrolase class that catalyzes cleavage of the leucine-leucine bond in angiotensinogen (a serum globulin) to generate angiotensin I (decapeptide hormone) in the liver. Among angiotensin I's various biological activity, it acts mainly as a precursor to angiotensin II (octapeptide hormone) which is a vasopressor and stimulator of aldosterone secretion by the adrenal cortex, and functions also as a neurotransmitter. A. II is formed by catalytic action of the hydrolase called peptidyl-dipeptidase A (EC 3.4.15.1) on C-terminal oligopeptide (A.I). In case of the cleavage of A. I to the activated A.II, it is called angiotensin-converting enzyme (ACE); in case of the cleavage and inactivation of kinins, it is called kininase II (also called dipeptidyl carboxypeptidase I). Angiotensin III (heptapeptide) is a  degradation product of A. II, having less vasopressor activity than the parent compound. The renin-angiotensin system plays an important role in the regulation of blood volume and blood pressure, stimulates antidiuretic hormone and aldosterone production, and the hypothalamus to activate the thirst reflex, but is crucial in the pathogenesis of hypertension patients due to blood vessels constrict, retention of fluid and raising blood pressure. ACE inhibitors prevent A.I from converting into A.II. and act to widen the blood vessels and make it easier for the heart to pump blood through the body. If high blood pressure continues for a long time, it  may damage the blood vessels of the brain, heart, and kidneys, resulting in heart attack, heart failure, or kidney failure. ACE inhibitors are used in ther treatment of hypertension, congestive heart failure, and to alleviate strain on hearts damaged as a result of a heart attack. They prevent from cardiovascular disorders, left ventricular dysfunction, and nephropathy in diabetes mellitus. They also helps control the amount of blood in your body. Angiotensin receptor blockers (ARBs) reduce hypertension by displacing A.II 2 from receptors on the surface of cells. There are  A.I receptor as well as A.II receptor. They are used when patients are intolerant of ACE inhibitor therapy. They have fewer side effects.

Angiotensin-Converting enzyme Inhibitors

  • Benazepril (CAS #: 86541-75-5)
  • Captopril (CAS #: 62571-86-2)
  • Enalapril (CAS #: 75847-73-3)
  • Fosinopril (CAS #: 98048-97-6)
  • Imidapril (CAS #: 89371-37-9)
  • Lisinopril (CAS #: 83915-83-7)
  • Moexipril (CAS #: 103775-10-6)
  • Quinapril (CAS #: 85441-61-8)
  • Perindopril (CAS #: 82834-16-0)
  • Ramipril (CAS #: 87333-19-5)
  • Trandolapril (CAS #: 87679-37-6)

Angiotension II Receptor Blockers

  • Candesartan (CAS #: 145040-37-5)
  • Eprosartan (CAS #: 133040-01-4)
  • Irbesartan (CAS #: 138402-11-6)
  • Losartan (CAS #: 114798-26-4)
  • Olmesartan (CAS #: 144689-24-7)
  • Telmisartan (CAS #: 144701-48-4)
  • Valsartan (CAS #: 137862-53-4)

Irbesartan is a non-peptide angiotensin II receptor (AT-1 subtype) antagonist. It is a white crystalline powder; melting point 221 - 223 C; insoluble in water, slightly soluble in alcohol and methylene chloride; administered orally. Chemical designation is 2-butyl-3-[[ 29-( 1H-tetrazol-5-yl) [1, 19-biphenyl]-4-yl] methyl]1,3- diazaspiro [4,4] non-1-en-4-one.

SALES SPECIFICATION

APPEARANCE

white crystalline powder

IDENTIFICATION

Complies Test A,B

ASSAY

99.0% min

LOSS ON DRYING

1.0% max

RELATED SUBSTANCE

0.5% max

HEAVY METALS

10ppm max

SULFATED ASH

0.1% max

TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: XI, Risk Phrases: 36/37/38, Safety Phrases: 26-36
PRICE INFORMATION

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