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| KETOCONAZOLE | ||
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PRODUCT IDENTIFICATION |
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| CAS NO. | 65277-42-1 |
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| EINECS NO. | 265-667-4 | |
| FORMULA | C26H28Cl2N4O4 | |
| MOL WT. | 531.44 | |
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H.S. CODE |
2941.90 | |
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TOXICITY |
Oral rat LD50: 86mg/kg | |
| SMILES |
Imidazole |
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| SYNONYMS | Fungarest; | |
| Fungoral; Ketoconazol; Panfungol; Fungoral; Nizoral; Ketoderm; Ketoisdin; Orifungal M; (±)-cis-1-Acetyl-4-(4-[(2-[2,4-dichlorophenyl]-2-[1H-imidazol-1- ylmethyl]- 1,3- dioxolan- 4-yl)- methoxy]phenyl)piperazine; | ||
| CLASSIFICATION |
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PHYSICAL AND CHEMICAL PROPERTIES |
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| PHYSICAL STATE | white to off white crystalline powder | |
| MELTING POINT | 148 - 152 C | |
| BOILING POINT |
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| SPECIFIC GRAVITY |
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| SOLUBILITY IN WATER | Insoluble | |
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SOLVENT SOLUBILITY |
soluble in methanol, acids, ethanol (slightly) | |
| pH | ||
| VAPOR DENSITY |
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REFRACTIVE INDEX |
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| AUTOIGNITION |
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| NFPA RATINGS | ||
| FLASH POINT |
Considered to be not inflammable | |
| STABILITY |
Stable under ordinary conditions | |
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APPLICATIONS |
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| Ketoconazole, an imidazole-containing fungistatic compound, is used as a broad-spectrum antifungal agent for the treatment or prevention of fungal infections especially against thrush, gastrointestinal infections, and infections of the skin, nails, and scalp. Chemical designation is cis-1-acetyl-4-[4-[[2-(2,4-dichloro phenyl)-2- (1H-imidazol-1- ylmethyl)-1,3-dioxolan-4- yl]methoxyl] phenyl] piperazine. It is also topically used in the formulation of cosmetic creams and in shampoos as a anti-dandruff agent. | ||
| SALES SPECIFICATION (USP23) | ||
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APPEARANCE |
white to off white crystalline powder | |
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ASSAY |
98.0% - 102.0% (Anhydrous Basis) | |
| MELTING POINT | 148 C - 152 C | |
| Specific Rotation |
-1° ~ +1° |
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HEAVY METALS |
20ppm max |
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| Residue on Ignition |
0.1% max (on dry basis) |
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| TRANSPORTATION | ||
| PACKING |
25kg in drum | |
| HAZARD CLASS | ||
| UN NO. | ||
| OTHER INFORMATION | ||
| Hazard Symbols: T, Risk Phrases: R 25/36/37/38/40/63, Safety Phrases: 22/26/32 | ||
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PRICE INFORMATION |
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