LAMIVUDINE

LAMIVUDINE
PRODUCT IDENTIFICATION
CAS NO.	134678-17-4
EINECS NO.
FORMULA	C₈H₁₁N₃O₃S
MOL WT.	229.25
H.S. CODE
TOXICITY
SYNONYMS	Epivir; (-)-2'-Deoxy-3'-thiacytidine;
(2R, cis)-4-amino-1-(2-hydroxymethyl-1 ,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one; (-) 2',3'- Dideoxy- 3' -thiacytidine; 3TC; 3'-thia-2',3'-dideoxcytidine;
CLASSIFICATION
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	white to off-white crystalline powder
MELTING POINT	186 - 188 C
BOILING POINT
SPECIFIC GRAVITY
SOLUBILITY IN WATER	soluble
pH
VAPOR DENSITY
AUTOIGNITION
NFPA RATINGS
REFRACTIVE INDEX
FLASH POINT
STABILITY	Stable under ordinary conditions.
APPLICATIONS
Lamivudine, an analogue of nucleoside, is an inhibitor of reverse transcriptase used as an antiretroviral agent that inhibits replication of some retroviruses in combination with zidovudine in the management of HIV (human immunodeficiency virus) reverse transcriptase and chronic viral hepatitis within cells. It is a white to off-white crystalline powder; melting point 175 - 178 C; soluble in water; administered orally. The chemcial designation is (2R, cis)-4-amino-1-(2-hydroxymethyl-1 ,3-oxathiolan-5-yl)-(1H)- pyrimidin-2-one. Protease inhibitors are the second class of antiretroviral drugs for the treatment of HIV. Aantiretroviral agents Non-nucleoside reverse transcriptase inhibitors Delavirdine [CAS #: 136817-59-9] Delavirdine mesylate [CAS #: 147221-93-0] Efavirenz [CAS #: 154598-52-4] Nevirapine [CAS #: 129618-40-2] Nucleoside/Nucleotide reverse transcriptase inhibitors Abacavir [CAS #: 136470-78-5] Abacavir succinate [CAS #: 168146-84-7] Abacavir sulfate [CAS #: 188062-50-2] Adefovir [CAS #: 106941-25-7] Adefovir dipivoxil [CAS #: 142340-99-6] Combivir (Lamivudine/Zidovudine mixture) [CAS #: 165456-81-5] Didanosine [CAS #: 69655-05-6] Emtricitabine [CAS #: 143491-57-0] Lamivudine [CAS #: 134678-17-4] Lamivudine sulfoxide [CAS #: 160552-55-6] Pradefovir mesylate [CAS #: 625095-61-6] Stampidine [CAS #: 217178-62-6] Stavudine [CAS #: 3056-17-5] Tenofovir [CAS #: 147127-20-6] Tenofovir disoproxil [CAS #: 201341-05-1] Tenofovir Disoproxil Fumarate [CAS #: 202138-50-9] Trizivir (Abacavir sulfate/Lamivudine/Zidovudine mixture) [CAS #: 364057-50-1] Zalcitabine [CAS #: 7481-89-2] Zidovudine [CAS #: 30516-87-1] Zidovudine sodium salt [CAS #: 106060-86-0] Protease inhibitors Amprenavir [CAS #: 161814-49-9] Atazanavir [CAS #: 198904-31-3] Atazanavir sulfate [CAS #: 229975-97-7] Fosamprenavir [CAS #: 226700-79-4] Fosamprenavir calcium [CAS #: 226700-81-8] Fosamprenavir sodium [CAS #: 226700-80-7] Indinavir [CAS #: 150378-17-9] Indinavir hydrate [CAS #: 180683-37-8] Indinavir Sulfate [CAS #: 157810-81-6] Kaletra (Lopinavir/Ritonavir mixture) [CAS #: 369372-47-4] Lopinavir [CAS #: 192725-17-0 Nelfinavir [CAS #: 159989-64-7] Nelfinavir mesylate [CAS #: 159989-65-8] Ritonavir [CAS #: 155213-67-5] Saquinavir [CAS #: 127779-20-8] Saquinavir mesylate [CAS #: 149845-06-7] Tipranavir [CAS #: 174484-41-4] Tipranavir disodium [CAS #: 191150-83-1]
SALES SPECIFICATION
APPEARANCE	White to off-white crystalline powder
ASSAY	98.0 - 102.0%
RESIDUE ON IGNITION	0.25% max
LOSS ON DRYING	0.5% max
OPTICAL ROTATION	-93° ~ -100°
HEAVY METALS	20ppm max
TRANSPORTATION
PACKING
HAZARD CLASS
UN NO.
OTHER INFORMATION
`Hazard Symbols: XN, Risk Phrases:` 22`, Safety Phrases: 22/24-45`
PRICE INFORMATION