MEMANTINE

MEMANTINE HYDROCHLORIDE
PRODUCT IDENTIFICATION
CAS NO.	19982-08-2 (Base), 41100-52-1 (Hydrochloride)
EINECS NO.
FORMULA	C₁₂H₂₁N·HCl
MOL WT.	215.77
H.S. CODE
TOXICITY
SYNONYMS	3,5-dimethyl-1-aminoadamantane hydrochloride;
1-Amino-3,5-dimethyltricyclo[3.3.1.1(3.7)] decane hydrochloride; 3,5-Dimethyltricyclo(3.3.1.1(3,7))decan-1-amine hydrochloride;
SMILES
CLASSIFICATION
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	white to off-white crystalline powder
MELTING POINT
BOILING POINT
SPECIFIC GRAVITY
SOLUBILITY IN WATER	soluble
pH	3.5 - 4.5
VAPOR DENSITY
AUTOIGNITION
NFPA RATINGS	Health: 2; Flammability: 0; Reactivity: 0
REFRACTIVE INDEX
FLASH POINT
STABILITY	Stable under ordinary conditions.
APPLICATION
Memantine is an NMDA(N-methyl-D-aspartate) receptor antagonist used to slow or reverse the neurodegenerative processes of Alzheimer's disease. It acts in the treatment of Alzheimer's disease. The hydrochloride salt of memantine is a white to off-white powder; soluble in water; administered orally. The chemical designation is 3,5-dimethyl-1-aminoadamantane hydrochloride or 1-Amino-3,5-dimethyltricyclo[3.3.1.1 (3.7)] decane hydrochloride.
SALES SPECIFICATION
APPEARANCE	white powder
IDENTIFICATION	pass Test A,B
ASSAY	98.5 - 100.5%
RELATED SUBSTANCE	1.0% max
SOLVENT RESIDUE	0.1% max
ASH	0.1% max
LOSS ON DRYING	0.5% max
HEAVY METALS	10ppm max
TRANSPORTATION
PACKING
HAZARD CLASS
UN NO.
GENERAL DESCRIPTION OF ADAMANTANE
Adamantane consists of four cyclohexanes fused each other in chair conformations. It is the most stable isomer of formula, C10H16; one of the highest melting point hydrocarbons (> 210 C); boiling point cannot be determined directly as it sublimes easily. Its stability is from strain free and highly symmetrical structure (all C-C bonds are set in and all Cs are tetrahedral). Its systematical name is tricyclo[3.3.1.1(3,7)]decane which means bicyclo[3.3.1]decane with an extra one-carbon bridge between C3 and C7. An alkyl substituent is axial in one ring and equatorial in another. Polymantanes have the same structure as the diamond lattice featuring highly symmetrical and strain free and are named as diamondoids . The general molecular formula of homologous diamondoid is C_4n+6H_4n+12. Diamondoids have one or more cages and are called diamantane, triamantane, and polymantanes. There are numerous structural isomers as well. Aadamantane itself is the simplest diamondoid. Some examples are; iceane (C₁₂H₁₈), diadamantane (C₁₄H₂₀), triadamantane (C₁₈H₂₄), isotetramantane (C₂₂H₂₈), cyclohexamantane (C₂₆H₃₀), superadamantane (C₃₅H₃₆). Natural diamondoids are extracted and purified from petroleum deposits. Diamondoids are being investigated in the new field of nanotechnoloy. Clinically, amantane and its derivatives are employed chiefly for the synthesis of antiviral drugs as well as neurological drugs such as rimantadine and Parkinson’s disease drugs. Their unique structures have the possibility to be applied to produce a broad range of biologically and pharmaceutically active drugs such as anticancer and anti-microbial agents.
PRICE