| CAS
NO. |
21829-25-4 |
|
| EINECS
NO. |
244-598-3 |
| FORMULA |
C17H18N2O6 |
| MOL
WT. |
346.34 |
|
H.S.
CODE
|
|
|
TOXICITY
|
|
| SYNONYMS |
Adalat; Procardia; Nifecard; Nyefax;
Nifedin; Citilat; |
|
4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine
3,5-pyridine dicarboxylicacid;
1,4-Dihydro-2,6- dimethyl-4-(2-nitrophenyl)-3,5-pyridine dicarboxylic acid, dimethyl ester;
Cordipin; Nifedipinum; Dimethyl
1,4-dihydro-2,6-dimethyl-4-(2'- nitrophenyl)- 3,5-pyridinedicarboxylate; |
|
SMILES |
|
|
CLASSIFICATION
|
|
|
PHYSICAL
AND CHEMICAL PROPERTIES
|
| PHYSICAL
STATE |
yellow
crystalline powder |
| MELTING
POINT |
171
- 175 C |
| BOILING
POINT |
|
| SPECIFIC
GRAVITY |
|
| SOLUBILITY
IN WATER |
Insoluble |
| pH |
|
| VAPOR
DENSITY |
|
|
AUTOIGNITION
|
|
|
NFPA
RATINGS
|
|
|
REFRACTIVE
INDEX
|
|
| FLASH
POINT |
|
| STABILITY |
Stable
under ordinary conditions. |
|
APPLICATIONS
|
| Calcium ions are needed for electrical activity for the contraction of
cardiac and smooth muscle and conduction of nerve cell. Calcium channel blocker
is a drug which inhibits the entry of excess calcium into cells and/or prevents
form the mobilization of calcium from intracellular stores, resulting in
relaxation of blood vessel walls and cardiac muscle for blood to flow more
freely, lowering blood pressure thereby reducing oxygen demand in the heart and
relieving anginal pain. It is used in the treatment of angina, cardiac
arrhythmias, and hypertension.
Some major calcium channel blockers upon
chemical structure are:
- Dihydropyridine calcium channel blockers ;
Amlodipine, Lacidipine, Lercanidipine, Nicardipine, Nifedipine, Nisoldipine, Nitrendipine,
Nimodipine.
- Phenylalkylamine calcium channel blockers ; Gallopamil,
Verapamil
- Benzothiazepine calcium channel blockers
Diltiazem
- Diarylaminopropylamine ethers: Bepridil, Mibefradil
Nifedipine is used as a coronary vasodilator and an antianginal in the
treatment of coronary insufficiency and angina of effort. The chemical
designation is
1,4-Dihydro-2,6-dimethyl-4-(2- nitrophenyl)-3,5- pyridine dicarboxylic acid,
dimethyl ester; It is a yellow
crystalline powder; insoluble in water , soluble in ethanol; melting point 171 -
175 C; administered orally.
|
| SALES
SPECIFICATION |
|
APPEARANCE
|
yellow
crystalline powder |
|
IDENTIFICATION
|
Complies
Test A,B
|
|
ASSAY
(HPLC)
|
98.0
- 102.0%
|
|
IMPURITY |
1.0%
max
(Individual impurity: 0.2% max, Nitrosophenylpyridine: 0.2% max)
|
|
LOSS
ON DRYING
|
0.5%
max
|
|
CHLORIDE
|
0.02%
max
|
|
SULFATE
|
0.05%
max
|
|
HEAVY
METALS
|
10ppm
max
|
|
MELTING
POINT
|
171
- 175 C
|
| TRANSPORTATION |
| PACKING |
|
| HAZARD
CLASS |
|
| UN
NO. |
|
| OTHER
INFORMATION |
| Hazard Symbols: XN, Risk Phrases: 20/21/22,
Safety Phrases: 36 |
| PRICE
INFORMATION |
| 
|
