NITROXOLINE (5-NITRO-8-HYDROXYQUINOLINE)

NITROXOLINE
PRODUCT IDENTIFICATION
CAS NO.	4008-48-4
FORMULA	C₉H₆N₂O₃
MOL WT.	190.16
H.S. CODE
TOXICITY	Oral rat LD50 : 510 mg/kg
SYNONYMS	5-Nitro-8-Hydroxyquinoline;
8-Hydroxy-5-nitroquinoline; 5-Nitro-8-quinolinol;
CLASSIFICATION	8-QUINOLINOLS / ANTISEPTICS /
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	Yellow crystalline powder, odorless
MELTING POINT	179 - 181 C
BOILING POINT
SPECIFIC GRAVITY
SOLUBILITY IN WATER	soluble (and soluble in hot glacial acetic acid, dioxane, but insoluble alcohol and ether )
pH
VAPOR DENSITY
REFRACTIVE INDEX
NFPA RATINGS	Health: 1; Flammability: 0; Reactivity: 0
AUTOIGNITION
FLASH POINT
STABILITY	Stable under normal conditions
APPLICATIONS
Quinoline, hygroscopic, yellowish oily liquid, is an aromatic nitrogen compound characterized by a double-ring structure contains a benzene and a pyridine. (Pyridine is a ring structure compound of five carbon atoms with a nitrogen atom). These two rings are fused at two adjacent carbon atoms. Quinoline itself is the simplest member of the quinoline. It can be prepared by the distillation of coal tar or by synthesis from aniline. It is soluble in water as well as in alcohol, ether, and carbon disulfide. Isoquinoline differs from quinoline in nitrogen position. Quinoline family compounds are widely used as a parent compound to make drugs (especially anti-malarial medicines), fungicides, biocides, alkaloids, dyes, rubber chemicals and flavoring agents. They have antiseptic, antipyretic, and antiperiodic properties. They are also used as catalyst, corrosion inhibitor, preservative, and as solvent for resins and terpenes. They are used in transition-metal complex catalyst chemistry for uniform polymerization and luminescence chemistry. Aminoquinolines are a group of amebicidal and anti-malarial compounds including amodiaquine, chloroquine, and hydrochloroquine (amino group at 4- position) and primaquine (at 8- position). They are used as an anti-malaria and preparing other anti-malaria drugs. It is used in manufacturing oil soluble dyes, food colorants, pharmaceuticals, pH indicators and other organic compounds. Oxyquinoline, hydroxyquinoline at 8- position, is used as a bacteriostatic and fungistatic agent. It is used in preparing antiseptics, deodorants, antiperspirants, and fungicides. The sulfate salt of 8-hydroxyquinoline is used as a complexing agent for pharmaceuticals. 8-Quinolinol is used as a precipitating agent or chelating agent to separate metals. It is also used in formulating anti-dandruff agents for shampoo. Chlorquinaldol, 5,7-dichloro-2-methyl-8-hydroxyquinoline, has antibacterial, antifungal and amoebicidal activity with antieczematic and antipruritic properties; used topically in the treatment of cutaneous and vaginal infections. It is a similar agent to clioquinol. Clioquinol is one of the halogenated 8-quinolinols which are antibacterial, intestinal antiamebic, and vaginal trichomonacide agents. They are derived from 8-hydroxyquinoline, an antiseptic agent with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. Clioquinol, iodochlorohydroxyquinoline, is an antifungal with antieczematic and antipruritic properties. Clioquinol topical preparations are used to treat skin infections. It was administered orally in the treatment of amebic dysentery. The oral preparation is banned worldwide due to associated subacute myelo-optic neuropathy. Nitroxoline (5-Nitro-8-Hydroxyquinoline) pharmacological actions include urinary anti-infective, antifungal and disinfectants.
SALES SPECIFICATION
APPEARANCE	Yellow crystalline powder, odorless
CONTENT	99.0% min
MELTING POINT	178 - 180 C
LOSS ON DRYING	0.5% max
RESIDUE ON IGNITION	0.2% max
INORGANIC SALT	0.1% max
ORGANIC IMPURITY	0.6% max
HEAVY METALS	20ppm max
TRANSPORTATION
PACKING	20kgs in fiber drum
HAZARD CLASS
UN NO.
PRICE INFORMATION