PERPHENAZINE

PRODUCT IDENTIFICATION
CAS NO. 58-39-9

PERPHENAZINE

EINECS NO. 200-381-5
FORMULA C21H26ClN3OS
MOL WT. 403.97

H.S. CODE

  

TOXICITY

  
SYNONYMS Chlorperphenazine; Etrafon; Perphenazine; Trilafon;
4-(3-(2-Chlorophenothiazin-10-YL)propyl)-1-piperazineethanol; gamma-(4- (beta- Hydroxyethyl) piperazin-1-yl) propyl-2-chlorophenothiazine; 1-(2-Hydroxyethyl)- 4-(3-(2- chloro-10- phenothiazinyl) propyl) piperazine; 2-Chloro-10-(3-(4- (2-hydroxyethyl) piperazin- 1-yl) propyl)phenothiazine; 1',1-(2-Idrossietil)-4,3-(2-cloro-10-fenotiazil) propilpiperazina;
SMILES

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to yellowish crystalline powder
MELTING POINT 96 - 100C
BOILING POINT

 

SPECIFIC GRAVITY

 

SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 

REFRACTIVE INDEX

 

NFPA RATINGS

  

AUTOIGNITION

 

FLASH POINT

 

STABILITY Stable under normal conditions

APPLICATIONS
Perphenazine is a short-acting piperazine phenothiazine antipsychotic drug which exhibits a more propensity for producing extrapyramidal reactions than the group of phenothiazine antipsychotic drugs, and used orally and intramuscularly. It may occur less hypertension but less potentiating effect on CNS depressants, anesthetics sedating than the group of phenothiazine antipsychotic drugs.
SALES SPECIFICATION (USP)

APPEARANCE

white yellowish powder

IDENTIFICATION

pass Test A, B

ASSAY

99.0 - 101.0%

LOSS ON DRYING

0.5% max

SULFATED ASH

0.1% max

INDIVIDUAL IMPURITY

0.2% max (total 0.5% max)

HEAVY METALS

10ppm max
TRANSPORTATION
PACKING
small and bulk
HAZARD CLASS 6.1 (Packing Group: III)
UN NO. 2811
OTHER INFORMATION
Hazard Symbols: XN, Risk Phrases: 22-43, Safety Phrases: 28-36/37/39-45

GENERAL DESCRIPTION OF ANTIPSYCHOTIC AGENTS
The term antipsychotic refers to a group of drugs effective in the treatment of psychosis including schizophrenic, paranoid, schizoaffective, bipolar disorder, and other psychotic disorders. Traditional antipsychotic agents have phenothiazine  structure chemically. Phenothiazinene drugs are adrenergic blocking agents. Their pharmacologic actions including central nervous system depression, prolongation and potentiation of the effects of narcotic and hypnotic drugs, hypotensive activity, and antispasmodic, antihistaminic, and antiemetic activity. Other chemcial structures for antipsychotic drugs are diverse, they include thioxanthene, butyrophenone, dibenzoxazepine, dihydroindolone, benzisoxazole, and diphenylbutylpiperidine. Antipsychotic agents bind to dopamine, histamine, muscarinic cholinergic, a-adrenergic, and serotonin receptors. Blockade of dopaminergic transmission in various areas is known to be responsible for their major effects such as not only antipsychotic action by blockade in the mesolimbic and mesocortical areas and and antiemetic effects by blockade in the chemoreceptor trigger zone of the medulla but also extrapyramidal side effects (dystonia, akathisia, parkinsonism, and tardive dyskinesia) by blockade in the basal ganglia and sedation and autonomic side effects (orthostatic hypotension, blurred vision, dry mouth, nasal congestion, and constipation) by blockade of histamine, cholinergic, and adrenergic receptors. The antipsychotic agents may be divided by chemical group and and the decreased propensity of extrapyramidal side effects into two main groups and a new class which is being processed.
  • Typical Antipsychotic
    • Chlorpromazine (CAS #: 50-53-3, Phenothiazine with aliphatic side chain)
    • Promazine (CAS #: 58-40-2, Phenothiazine with aliphatic side chain)
    • Triflupromazine (CAS #: 146-54-3, Phenothiazine with aliphatic side chain)
    • Methotrimeprazine (CAS #: 60-99-1, Phenothiazine with aliphatic side chain)
    • Thioridazine (CAS #: 50-52-2, Phenothiazine with piperidine side chain)
    • Mesoridazine (CAS #: 5588-33-0, Phenothiazine with piperidine side chain)
    • Acetophenazine (CAS #:2751-68-0, Phenothiazine with piperazine side chain)
    • Perphenazine (CAS #: 58-39-9, Phenothiazine with piperazine side chain)
    • Trifluoperazine (CAS #: 117-89-5, Phenothiazine with piperazine side chain)
    • Fluphenazine (CAS #: 69-23-8, Phenothiazine with piperazine side chain)
    • Prochlorperazine (CAS #: 58-38-8, Phenothiazine with piperazine side chain)
    • Chlorprothixene (CAS #: 113-59-7 Thioxanthene)
    • Thiothixene (CAS #: 22189-31-7, Thioxanthene)
    • Haloperidol (CAS #: 52-86-8, Phenylbutylpiperadine)
    • Pimozide (CAS #: 2062-78-4, Phenylbutylpiperadine)
    • Loxapine (CAS #: 1977-10-2, Dibenzoxazepine)
    • Molindone (CAS #: 7416-34-4, Dihydroindolone)
  • Atypical Antipsychotics
    • Clozapine (CAS #: 5786-21-0, Dibenzoxazepine)
    • Olanzapine (CAS #: 132539-06-1, Dibenzoxazepine)
    • Quetiapine (CAS #: 111974-69-7, Dibenzoxazepine)
    • Ziprasidone (CAS #: 138982-67-9, Benzisoxazole)
    • Risperidone (CAS #: 106266-06-2, Benzisoxazole)
  • Partial dopamine agonists
    • Aripiprazole (CAS #: 129722-12-9, Dihydroquinolinone)
  • Lithium carbonate
PRICE INFORMATION

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