RIBAVIRIN

RIBAVIRIN

PRODUCT IDENTIFICATION

CAS NO.

36791-04-5; 437710-49-1; 66510-90-5

RIBAVIRIN

EINECS NO.

FORMULA

C₈H₁₂N₄O₅

MOL WT.

244.21

H.S. CODE

TOXICITY

SMILES

SYNONYMS

Ribaviran; Tribavirin;

1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide; Vilona; Viramid; Virazid; Virazole; 1-beta-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxamide;

CLASSIFICATION

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

White to off-white crystalline powder

MELTING POINT

BOILING POINT

SPECIFIC GRAVITY

SOLUBILITY IN WATER

VAPOR DENSITY

AUTOIGNITION

NFPA RATINGS

REFRACTIVE INDEX

FLASH POINT

STABILITY

Stable under ordinary conditions.

APPLICATIONS

Ribavirin is a synthetic nucleoside analog resembling guanosine; a white crystalline powder; soluble in water, slightly soluble in ethanol. It is a broad-spectrum antiviral against a number of DNA and RNA viruses. It is used in the treatment of severe viral pneumonia caused by respiratory syncytial virus, particularly a viral liver infection known as hepatitis C. Its chemical designation is 1-beta-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxamide. It is used in combination with injectable interferon or with peginterferon. Administered by oral inhalation.

Antimetabolite is a chemical compound that closely resembles a metabolite in molecular structure, but can interfering with the normal reactions of the essential metabolite. It prevent the cell from the utilization of the genuine substance necessary to normal biochemical reactions. Chemically modified nucleotides substituted or attached by special chemical groups or elements are studied and used to inactivate the normal biological operation in the living organism and the function of important enzymes. Aminopterin (4-aminofolic acid) and methotrexate (mthylaminopterin) are antagonists of folic acid, and used in the treatment of some neoplastic diseases. Azathioprine and mercaptopurine are purine antagonists. 5-Fluorouracil and fluorodeoxyuridine are examples of pyrimidine antagonists; used as an antineoplastic and as a component of chemotherapy regimens. DNA synthesis inhibitors for antitumor effects include:

SALES SPECIFICATION

APPEARANCE

White crystalline powder

IDENTIFICATION

Complies

ASSAY (HPLC)

98.5% - 102.0%

OPTICAL ROTATION

-33.5° ~ -37.0°

LOSS ON DRYING

0.5% max

HEAVY METALS

10ppm max

RESIDUE ON IGNITION

0.1% max

RELATED MATERIAL

1.0% max

TRANSPORTATION

PACKING

HAZARD CLASS

UN NO.

OTHER INFORMATION