SERTRALINE

SERTRALINE HYDROCHLORIDE

PRODUCT IDENTIFICATION

CAS NO.

79617-96-2 (Base), 79559-97-0 (HCl)

SERTRALINE

EINECS NO.

FORMULA

C₁₇H₁₇NC_l2·HCl

MOL WT.

342.73

H.S. CODE

TOXICITY

SYNONYMS

Zoloft®; Lustral®; Apo-Sertral®; Asentra®; Gladem®;

(1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine hydrochloride; Serlift®; Stimuloton®);

SMILES

CLASSIFICATION

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

white to off-white powder

MELTING POINT

246 - 249 C

BOILING POINT

SPECIFIC GRAVITY

SOLUBILITY IN WATER

SOLVENT SOLUBILITY

VAPOR DENSITY

AUTOIGNITION

NFPA RATINGS

REFRACTIVE INDEX

FLASH POINT

STABILITY

Stable under ordinary conditions.

APPLICATIONS

Sertraline is a drug of selective serotonin reuptake inhibitors (SSRI) which inhibit the inactivation of serotonin (5-hydroxytryptamine or 5-HT) by blocking its absorption in the central nervous system. The hydrochloride of sertraline is a a white crystalline powder; slightly soluble in water and alcohols (ethanol, isopropyl alcohol); melting point 246 - 249 C; administered orally. The chemical designation is (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine hydrochloride. SSRIs are used to treat depressions and effective for obsessive-compulsive disorder, posttraumatic stress disorder, premenstrual dysphoric mood disorder, panic disorder, generalized anxiety disorder, and bulimia. Drugs used to treat depressions include;

TRICYCLIC ANTIDEPRESSANTS

Amitriptyline [CAS #: 50-48-6, 549-18-8 (HCl)]

Amoxapine [CAS #: 14028-44-5]

Clomipramine [CAS #: 303-49-1]

Desipramine [CAS #: 50-47-5 58-28-6 (HCl)]

Doxepin [CAS #: 1668-19-5, 1229-29-4 (HCl)]
Imipramine [CAS #: 50-49-7, 113-52-0 (HCl)]
Nortriptyline [CAS #: 894-71-3 (HCl)]
Protriptyline [CAS #: 438-60-8, 1225-55-4(HCl)]
Trimipramine [CAS #: 739-71-9, 521-78-8 (Maleate)]

TETRACYCLIC ANTIDEPRESSANT
- Maprotiline [CAS #: 10262-69-8, 10347-81-6 (HCl)]

MONOAMINE OXIDASE INHIBITORS
- Isocarboxazid [CAS #: 59-63-2, 24631-64-9 (Sulfate)]
- Phenelzine [CAS #: 51-71-8, 156-51-4 (Sulfate)]
- Tranylcypromine [CAS #: 155-09-9]

SELECTIVE SEROTONIN REUPTAKE INHIBITORS
- Fluoxetine [CAS #: 54910-89-3, 59333-67-4 (HCl)]
- Paroxetine [CAS #: 61869-08-7]
- Sertraline [CAS #: 79617-96-2, 79559-97-0 (HCl)]
- Escitalopram Oxalate [CAS #: 128196-01-0]
- Citalopram [CAS #: 59729-33-8, 59729-33-8 (HBr)]
- Fluvoxamine [CAS #: 54739-18-3, 6387-89-9 (Maleate)]

SEROTONIN-NOREPINEPHRINE REUPTAKE INHIBITOR
- Duloxetine [CAS #: 116539-59-4]

PSYCHOSTIMULANTS

Dextroamphetamine [CAS #: 51-64-9, 51-63-8 (Sulfate)]
Methylphenidate [CAS #: 113-45-1, 298-59-9 (HCl)]

MODIFIED ANTIDEPRESSANTS
- Trazodone [CAS #: 19794-93-5, 25332-39-2 (HCl)]
- Venlafaxine [CAS #: 93413-69-5, 99300-78-4 (HCl)]
- Nefazodone [CAS #: 83366-66-9]
- Mirtazapine [CAS #: 61337-67-5]
- Bupropion [CAS #: 31677-93-7]
- Buspirone [CAS #: 36505-84-7]
- Reboxetine [CAS #: 71620-89-8]

SALES SPECIFICATION

APPEARANCE

white to off-white powder

ASSAY

98.5% min

MELTING POINT

246 - 249 C

LOSS ON DRYING

0.5% max

RELATED SUBSTANCE

0.5% max

TRANSPORTATION

PACKING

HAZARD CLASS

UN NO.

PRICES