TRICLOSAN (2,4,4'-TRICHLORO-2'-HYDROXYDIPHENYL ETHER)

TRICLOSAN
PRODUCT IDENTIFICATION
CAS NO.	3380-34-5
EINECS NO.	222-182-2
FORMULA	C₁₂H₇Cl₃O₂
MOL WT.	289.55
H.S. CODE	2909.50
TOXICITY	Oral rat LD50: 5000mg/kg
SYNONYMS	2,4,4'-Trichloro-2'-hydroxydiphenyl ether;
Trichloro-2'-hydroxydiphenylether; 5-Chloro-2-(2,4-dichlorophenoxy)phenol; 2,4,4'-Trichloro-2-hydroxydiphenyl ether; 5-Chloro-2-(2,4- dichlorophenoxy) phenol;
SMILES
CLASSIFICATION	DISINFECTANTS /
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	white to off-white powder, weak odor
MELTING POINT	55 - 57 C
BOILING POINT
SPECIFIC GRAVITY
SOLUBILITY IN WATER	17 mg/l
pH
VAPOR DENSITY
AUTOIGNITION
NFPA RATINGS
REFRACTIVE INDEX
FLASH POINT
STABILITY	Stable under ordinary conditions
GENERAL DESCRIPTION & APPLICATIONS
Triclosan, a derivative of diphenyl ether, is a very popular antibacterial agent. It is insoluble in water; but fat-soluble. It disables the activity of the enzyme called ENR (enoyl-acyl carrier-protein reductase) which humans don't have. (So triclosan is harmless to human). This enzyme is vital in building cell membranes of many bacteria and funguses. Triclosan has a powerful antibiotic action even at very low concentrations as its one molecule blocks permanently one molecule of ENR. Triclocarban is an analogue of triclosan. Both are used in hospitals for cleansing and disinfecting the skin of patients and surgeons. It is used in cosmetics, household goods and personal care products. It is also used in plastics (children's toys) and textiles (kitchen and table goods) for antibacterial activity purpose.
SALES SPECIFICATION
APPEARANCE	white to off-white powder
PURITY	99.5% min
LOSS ON DRYING	0.1% max
MELTING POINT	55 - 57 C
HEAVY METALS	10ppm max
TRANSPORTATION
PACKING	25kgs in fiber drum
HAZARD CLASS	not regulated
UN NO.
OTHER INFORMATION
`Hazard Symbols: XI, Risk Phrases: 36/37/38, Safety Phrases: 26-36`
GENERAL DESCRIPTION OF ANTISEPTIC AGENT
Antiseptic agent is a substance which kills or inhibits the growth of disease-causing bacteria and other microorganisms. It is essentially nontoxic to be applied to the skin or mucous membranes. (Disinfectant including cresol, bleaching powder, and phenol is in general toxic to cells of the body). Common antiseptic agents are Benzalkonium Chloride, Cetrimide, Chlorhexidine, Hexachlorophene, Iodine Compounds, Mercury Compounds (Thimerosol), Alcohol and Hydrogen Peroxide, Hexamine Hippurate, Triclosan, Cetylpyridinium Chloride, And Dequalinium. Other substances which can be used for antiseptic purpose include Boric acid and volatile oils such as Methyl Salicylate. Hexachlorophene and Benzalkonium Chloride are used primarily in hand or face washes. Benzalkonium Chloride must not be applied to areas which have not been fully rinsed as it is inactivated by organic compounds. Benzalkonium application many include disinfecting instruments and preservativing drugs in low concentration form. Iodine compounds have the widest spectrum of antiinfectives against bacteria, fungi, spores, protozoa, viruses, and yeasts. Aqueous iodine are less effective than alcoholic solutions, but alcoholic component is drying and irritating to abraided skin. Povidone iodine is convenient to use as it is less irritating, but not as effective. Chlorhexidine is used as a safe antiseptic or disinfectant to apply to prevent body infection and in oral rinses for treating sore gums and mouth ulcers and preventing plaque on teeth. It is used in the form of acetate, gluconate or hydrochloride, either alone or in combination with others such as cetrimide. Cetrimide is an antiseptic agent with detergent properties. It has the wide spectrum of antiinfectives against bacteria and fungi. It is used as an ingredient of shampoos for treating seborrhoea and psoriasis. A very dilute solution can be applied topically for the relief of sore gums. Hippuric Acid, an amino acid glycine, is excreted from the body and is used in urinary system drugs. Hexamine hippurates is helpful for preventing and treating infections of the urinary system; it acts by being transformed to formaldehyde. Triclosan is a very popular antibacterial agent. It is used in hospitals for cleansing and disinfecting the skin of patients and surgeons. It is used in cosmetics, household goods and personal care products. It is also used in plastics and textiles for antibacterial activity purpose. Cetylpyridinium chloride is used in oral rinses for cleaning mouth and treating minor throat or mouth infections and teething problems. Dequalinium chloride is antiinfectives against bacteria and fungi. It is used in treating bacterial or fungal infections of mouth and throat.
PRICE