TRIFLURIDINE (TRIFLUOROTHYMIDINE)

TRIFLURIDINE

PRODUCT IDENTIFICATION

CAS NO.

70-00-8

TRIFLURIDINE

EINECS NO. 200-722-8

FORMULA C₁₀H₁₁F₃N₂O₅

MOL WT. 296.20

H.S. CODE

TOXICITY

SYNONYMS Trifluorothymidine TFT

2'-Deoxy-5-(trifluoromethyl)uridine

alpha,alpha,alpha-Trifluoro thymidine Trifluorothymine deoxyriboside 5-(Trifluoromethyl)-2'- deoxyuridine

CLASSIFICATION

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white crystalline powder

MELTING POINT 190 - 193 C

BOILING POINT

SPECIFIC GRAVITY

SOLUBILITY IN WATER

soluble

VAPOR DENSITY

AUTOIGNITION

NFPA RATINGS

Health: 1 Flammability: 0 Reactivity: 0

REFRACTIVE INDEX

FLASH POINT

STABILITY Stable under ordinary conditions

GENERAL DESCRIPTION AND APPLICATIONS

Urasil is a pyrimidine base, occurring condensed with ribose or deoxyribose to form the nucleosides uridine and deoxyuridine in animal cells. It is a fundamental unit or base of nucleic acids. When N1 is linked to the C1 of ribose, urasil forms a pyrimidine nucleoside called uridines which are phosphorylated with from one to three phosphoric acid groups to form the three nucleotides uridine monophosphate (UMP), uridine diphosphate (UDP), and uridine triphosphate (UTP) respectively. When N1 is linked to the C1 of deoxyribose, deoxy nucleosides and nucleotides are formed from urasil and deoxyribose deoxyuridine monophosphate (dUMP), deoxyuridine diphosphate (dUDP), and deoxyuridine triphosphate (dUTP). UTP is an activated precursor in the synthesis of UDP-linked hexoses. UDP acts as the chief transferring coenzyme in carbohydrate metabolism to produce sucrose in plants, lactose and glycogen in mammals, and chitin in insects. UTP is involved in the formation of adenosine triphosphate (ATP) as a donator of phosphate groups to adenosine diphosphate (ADP). Uridine is important in biosynthesis of DNA and in the preservation and transfer of genetic information. It is known that there is no uridine in ribonucleic acid (RNA) the uridine nucleotides contain only deoxyribose.

Urasil: a pyrimidine base
Uridinea pyrimidine nucleoside
Uridine Monophosphate (UMP, Uridylic acid): a nucleotide, the 5'-phosphate of uridine a component of ribonucleic acid.
Uridine Diphosphate (UDP): a nucleotide, the 5'-pyrophosphate of uridine acting as the chief transferring coenzyme in carbohydrate metabolism acting as a carrier of hexoses, hexosamines, and hexuronic acids which are intermediates in the metabolism.
Uridine Triphosphate (UTP): a nucleotide, the 5'-triphosphate of uridine acting as a precursor in the synthesis of ribonucleic acid and of UDP-linked intermediates.
Deoxyuridine Monophosphate (dUMP): a nucleotide, the 5'-phosphate of deoxyuridine an intermediate in the synthesis of deoxythymidine triphosphate. (deoxy-, also called desoxy, is a prefix for the designation of compounds which contain one less atom of oxygen than the reference substance).
Deoxyuridine Diphosphate (dUDP): a nucleotide, the 5'-phosphate of deoxyuridine an intermediate in the synthesis of deoxythymidine triphosphate.
Deoxyuridine Triphosphate (dUTP): a nucleotide, the 5'-triphosphate of deoxyuridine an intermediate in the synthesis of deoxyribonucleotides.

Chemically modified nucleotides substituted or attached by special chemical groups or elements are studied and used to inactivate the normal biological operation in the living organism and the function of important enzymes.

Antimetabolite is a chemical compound that closely resembles a metabolite in molecular structure, but can interfering with the normal reactions of the essential metabolite. It prevent the cell from the utilization of the genuine substance necessary to normal biochemical reactions. Chemically modified nucleotides substituted or attached by special chemical groups or elements are studied and used to inactivate the normal biological operation in the living organism and the function of important enzymes. Aminopterin (4-aminofolic acid) and methotrexate (mthylaminopterin) are antagonists of folic acid, and used in the treatment of some neoplastic diseases. Azathioprine and mercaptopurine are purine antagonists. 5-Fluorouracil and fluorodeoxyuridine are examples of pyrimidine antagonists used as an antineoplastic and as a component of chemotherapy regimens. DNA synthesis inhibitors for antitumor effects include:

SALES SPECIFICATION

APPEARANCE

white crystalline powder

ASSAY

98.0 - 102.0%

LOSS ON DRYING 0.5% max

TRANSPORTATION

PACKING

HAZARD CLASS Not regulated

UN NO.

OTHER INFORMATION

Hazard Symbols: XN, Risk Phrases: 20/21/22-40, Safety Phrases: 22-36
Price:

GENERAL DESCRIPTION OF PURINE

Purine is a heterocyclic compound featured by a fused pyrimidine and imidazole rings composed of carbon and nitrogen atoms. The simplest one is purine itself and the two major purines are adenine(6-Aminopurine) and guanine(2-Amino-6-hydroxypurine). Other important purines are caffeine, uric acid, theobromine, and theophylline. Purine and its derivatives are biologically important components of nucleic acids (DNA, RNA) and coenzymes.