ZIPRASIDONE HYDROCHLORIDE HYDRATE

PRODUCT IDENTIFICATION
CAS NO. 138982-67-9

ZIPRASIDONE
EINECS NO.  
FORMULA C21H21ClN4OS·HCl·H2O
MOL WT. 467.39

H.S. CODE

  

TOXICITY

 
SMILES

 
SYNONYMS

 
5-(2-(4-(1,2-Benzisothiazol-3-yl)piperazinyl)ethyl)-6-chloro-1,3-dihydro-2(1H)-indole-2- one ydrochloride hydrate;

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to off-white crystalline powder
MELTING POINT >300 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 
AUTOIGNITION

 
NFPA RATINGS

 

REFRACTIVE INDEX

  
FLASH POINT

 
STABILITY

Stable under ordinary conditions

APPLICATIONS
Ziprasidone, a benzothiazolylpiperazine derivative, is an atypical antipsychotic agent to treat psychiatric conditions such as schizophrenia, hallucinations, delusions, hostility and other bipolar disorder without increase of lipids and and other blood fats. It is chemically described as 5-(2-(4-(1,2-Benzisothiazol-3-yl)piperazinyl)ethyl)-6-chloro-1,3-dihydro-2(1H)-indole-2-one. The hydrochloride hydrate form of ziprasidone an off-white powder; melting point 300 C; administered orally.
SALES SPECIFICATION

APPEARANCE

 off-white powder

IDENTIFICATION

Complies Test A,B
ASSAY

99.0% min

LOSS ON DRYING

1.0% max

RELATED SUBSTANCE

0.5% max

HEAVY METALS

20ppm max
SULFATED ASH

0.1% max
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  

GENERAL DESCRIPTION OF ANTIPSYCHOTIC AGENTS
The term antipsychotic refers to a group of drugs effective in the treatment of psychosis including schizophrenic, paranoid, schizoaffective, bipolar disorder, and other psychotic disorders. Traditional antipsychotic agents have phenothiazine  structure chemically. Phenothiazinene drugs are adrenergic blocking agents. Their pharmacologic actions including central nervous system depression, prolongation and potentiation of the effects of narcotic and hypnotic drugs, hypotensive activity, and antispasmodic, antihistaminic, and antiemetic activity. Other chemcial structures for antipsychotic drugs are diverse, they include thioxanthene, butyrophenone, dibenzoxazepine, dihydroindolone, benzisoxazole, and diphenylbutylpiperidine. Antipsychotic agents bind to dopamine, histamine, muscarinic cholinergic, a-adrenergic, and serotonin receptors. Blockade of dopaminergic transmission in various areas is known to be responsible for their major effects such as not only antipsychotic action by blockade in the mesolimbic and mesocortical areas and and antiemetic effects by blockade in the chemoreceptor trigger zone of the medulla but also extrapyramidal side effects (dystonia, akathisia, parkinsonism, and tardive dyskinesia) by blockade in the basal ganglia and sedation and autonomic side effects (orthostatic hypotension, blurred vision, dry mouth, nasal congestion, and constipation) by blockade of histamine, cholinergic, and adrenergic receptors. The antipsychotic agents may be divided by chemical group and and the decreased propensity of extrapyramidal side effects into two main groups and a new class which is being processed.
  • Typical Antipsychotic
    • Chlorpromazine (CAS #: 50-53-3, Phenothiazine with aliphatic side chain)
    • Promazine (CAS #: 58-40-2, Phenothiazine with aliphatic side chain)
    • Triflupromazine (CAS #: 146-54-3, Phenothiazine with aliphatic side chain)
    • Methotrimeprazine (CAS #: 60-99-1, Phenothiazine with aliphatic side chain)
    • Thioridazine (CAS #: 50-52-2, Phenothiazine with piperidine side chain)
    • Mesoridazine (CAS #: 5588-33-0, Phenothiazine with piperidine side chain)
    • Acetophenazine (CAS #:2751-68-0, Phenothiazine with piperazine side chain)
    • Perphenazine (CAS #: 58-39-9, Phenothiazine with piperazine side chain)
    • Trifluoperazine (CAS #: 117-89-5, Phenothiazine with piperazine side chain)
    • Fluphenazine (CAS #: 69-23-8, Phenothiazine with piperazine side chain)
    • Prochlorperazine (CAS #: 58-38-8, Phenothiazine with piperazine side chain)
    • Chlorprothixene (CAS #: 113-59-7 Thioxanthene)
    • Thiothixene (CAS #: 22189-31-7, Thioxanthene)
    • Haloperidol (CAS #: 52-86-8, Phenylbutylpiperadine)
    • Pimozide (CAS #: 2062-78-4, Phenylbutylpiperadine)
    • Loxapine (CAS #: 1977-10-2, Dibenzoxazepine)
    • Molindone (CAS #: 7416-34-4, Dihydroindolone)
  • Atypical Antipsychotics
    • Clozapine (CAS #: 5786-21-0, Dibenzoxazepine)
    • Olanzapine (CAS #: 132539-06-1, Dibenzoxazepine)
    • Quetiapine (CAS #: 111974-69-7, Dibenzoxazepine)
    • Ziprasidone (CAS #: 138982-67-9, Benzisoxazole)
    • Risperidone (CAS #: 106266-06-2, Benzisoxazole)
  • Partial dopamine agonists
    • Aripiprazole (CAS #: 129722-12-9, Dihydroquinolinone)
  • Lithium carbonate
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