ACYCLOVIR

ACYCLOVIR
PRODUCT IDENTIFICATION
CAS NO.	59277-89-3
EINECS NO.	261-685-1
FORMULA	C₈H₁₁N₅O₃
MOL WT.	225.20
H.S. CODE
TOXICITY
SYNONYMS	2-Amino-9-(2-hydroxyethoxymethyl)-3H-purin-6-one
2-Amino-1,9-dihydro-9-((2-hydroxyethoxy)methyl)-6H-purin-6-one; Acycloguanosine; Acyclovir; Vipral; Virorax; Zovirax; 2-Amino-1,9-dihydro-9-((2-hydroxyethoxy)-methyl)-6H-Purin-6-one; 9-((2-Hydroxyethoxy)methyl)guanine; ACV; Aciclovirum; Aciclovirum; 9-[(2-Hydroxyethoxy)methyl]guanine;
DERIVATION
CLASSIFICATION
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	white to off-white crystalline powder
MELTING POINT
BOILING POINT
RELATIVE DENSITY
SOLUBILITY IN WATER	Insoluble
pH
VAPOR DENSITY
REFRACTIVE INDEX
NFPA RATINGS
AUTOIGNITION
FLASH POINT
STABILITY	Stable under normal conditions.
GENERAL DESCRIPTION & APPLICATIONS
Acyclovir is a partial nucleoside. It is a functional analog of the guanosine. Chemically acycloguanosine has an open-chain structure instead of the sugar ring. It is selectively and rapidly converted into the acyclo-guanosine monophosphate (acyclo-GMP) by highly affinitive thymidine kinase after administration in the cell. The monophosphate is further converted into diphosphate and into subsequently triphosphate by a number of cellular kinases. Acyclovir triphosphate terminates replication of herpes viral DNA. Acyclovir is a synthetic acyclic purine nucleoside analogue with selective antiviral activity predominantly against herpes simplex virus type I (HSV-1) and herpes simplex virus type II (HSV-2). Acyclovir is also active against varicella zoster virus (VZV), epstein-Barr virus (EBV) and cytomegalovirus (CMV) It is inactive against latent viruses in nerve ganglia. In addition to aciclovir (prodrug: valaciclovir) antivirals against herpes simplex virus include cidofovir, docosanol, famciclovir, fomivirsen, foscarnet, ganciclovir, idoxuridine, penciclovir, trifluridine, tromantadine, valaciclovir, valganciclovir, and vidarabine Valaciclovir is the prodrug which is converted to the active aciclovir in vivo by esterase.
SALES SPECIFICATION
APPEARANCE	white to off-white crystalline powder
IDENTIFICATION	to pass test A, B, C
ASSAY	98.5 - 100.5%
ORGANIC IMPURITY	1.0% max
HEAVY METALS	10ppm max
GUANINE	0.7% max
LOSS ON DRYING	6.0% max
TRANSPORTATION
PACKING
HAZARD CLASS
UN NO.
PRICE