CLOPAMIDE

CLOPAMIDE

PRODUCT IDENTIFICATION

CAS NO.

636-54-4

CLOPAMIDE

EINECS NO.

211-261-7

FORMULA

C₁₄H₂₀ClN₃O₃S

MOL WT.

345.85

H.S. CODE

TOXICITY

DERIVATION

CLASSIFICATION

SYNONYMS

Aquex; Clopamida; Clopamide; Clopamidum;

4-Chloro-N-[(2R,6S)-2,6-dimethylpiperidin-1-yl]-3-sulfamoylbenzamide; cis-3-(aminosulfonyl)-4-chloro-N-(2,6-dimethyl-1-piperidinyl)benzamide; Clopamide; 4-Chloro-N-(cis-2,6-dimethylpiperidino)-3-sulfamoylbenzamide; 4-Chloro-N-(2,6-dimethylpiperidino)-3-sulfamoylbenzamide;

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

White to yellowish crystalline powder

MELTING POINT

BOILING POINT

SPECIFIC GRAVITY

SOLUBILITY IN WATER

VAPOR DENSITY

AUTOIGNITION

NFPA RATINGS

REFRACTIVE INDEX

FLASH POINT

STABILITY

Stable under ordinary conditions.

APPLICATIONS

Clopamide has piperidine moiety and is classified as a sulfamoyl diuretic. It has similar properties to thiazide class diuretics which act on the inhibiting reabsorption of sodium in the proximal renal tubule and stimulating chloride excretion, resulting in increasing excretion of water. Clopamide is used in the treatment of edema due to congestive heart failure or chronic hepatic or renal disease associated with various disorders and in hypertension. Class of diuretics are:

Potassium-sparing diuretics (Spironolactone, Eplerenone, Amiloride, Triamterene)
Xanthine derivatives (Caffeine, Theophylline, Aminophylline, Theobromine, Meralluride, Pamabrom)
Carbonic anhydrase inhibitors (Acetazolamide, Dorzolamide, Furosemide)
Loop diuretics (Furosemide, Bumetanide, Ethacrynic acid, Metolazone)
Thiazide derivatives (Hydrochlorothiazide, Bendroflumethiazide)
Osmotic diuretics (Sorbitol, Urea, Mannitol, Glucos, Isosorbide)

SALES SPECIFICATION

APPEARANCE

White to yellowish crystalline powder

IDENTIFICATION

pass Test

ASSAY

98.0 - 102.0 %

MELTING POINT

230 - 232 C

LOSS ON DRYING

2.5% max

SULFATED ASH

0.2% max

HEAVY METALS

20ppm max

TRANSPORTATION

PACKING

HAZARD CLASS

UN NO.

PRICES