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| DIACERHEIN | ||
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PRODUCT IDENTIFICATION |
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| CAS NO. | 13739-02-1 |
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| EINECS NO. | 237-310-2 | |
| FORMULA | C19H12O8 | |
| MOL WT. | 368.29 | |
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H.S. CODE |
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TOXICITY |
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| SYNONYMS | Diacereinum; Diacerein; Diacetylrhein; | |
| Diacetylrhein; 1,8-Diacetoxyanthraquinone-3-carboxylic acid; 4,5-Diacetylrhein; 4,5-Diacetoxy-9,10-dihydro-9,10-dioxo-2-anthrylcarbonsaeure; Artrodar; Diacereina; Diacereine; 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthroic acid diacetate; Fisiodar; Rhein diacetate; 4,5-Diacetyloxy-9,10-dioxoanthracene-2-carboxylic acid; 1,8-Diacetoxy-3-carboxyanthraquinone; 9,10-Dihydro-4,5-diacetoxy-9,10-2-anthracenecarboxylic acid; | ||
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CLASSIFICATION |
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PHYSICAL AND CHEMICAL PROPERTIES |
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| PHYSICAL STATE |
Slightly yellowish crystalline powder | |
| MELTING POINT | 217 - 218 C | |
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REFRACTIVE INDEX |
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NFPA RATINGS |
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AUTOIGNITION |
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FLASH POINT |
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| STABILITY | Stable under normal conditions. | |
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GENERAL DESCRIPTION & APPLICATIONS |
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| Rhein (1,8-Dihydroxyanthraquinone-3-carboxylic acid) is an anthraquinone-related compound found in several plants especially Rhamnus frangula. It is an enzyme inhibitor that binds to enzymes and decrease their activity, which leads killing a pathogen or correcting a metabolic imbalance. Natural poisons are often enzyme inhibitors that have evolved to defend a plant or animal against predators. Many insecticides (such as malathion), herbicides (glyphosate), and disinfectants (triclosan) are enzyme inhibitors. They are also designed as part of pharmacology and biochemistry to treat disease. They are used as tool in toxicity studies. Diacerein, diester of rhein, is metabolized to active rhein. It is a slow acting symptomatic drug used in the treatment of osteoarthritis by inhibiting interleukin-1 and metalloproteinases. But it has no effect of cyclooxygenase. One of the closely related compound with Rhein is Emodin (1,3,8-Trihydroxy-6-methyl-9,10-anthraquinone). | ||
| SALES SPECIFICATION | ||
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APPEARANCE |
Slightly yellowish crystalline powder |
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ASSAY |
98.0% min |
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HEAVY METALS |
10ppm max |
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| RESIDUE ON IGNITION |
0.1% max |
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| LOSS ON DRYING | 0.2% max | |
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| HAZARD CLASS | ||
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| OTHER INFORMATION | ||
| Hazard Symbols: XI, Risk Phrases: 36/37/38, Safety Phrases: 26-36 | ||
| PRICE INFORMATION | ||
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