| CAS
NO. |
96829-58-2;
111397-16-1 |
|
| EINECS
NO. |
|
| FORMULA |
C29H53NO5 |
| MOL
WT. |
495.73 |
|
H.S.
CODE
|
|
|
TOXICITY
|
|
|
CLASSIFICATION
|
|
| SYNONYMS |
(-)-Tetrahydrolipstatin;
Tetrahydrolipstatin; Xenical; |
|
1-(3-Hexyl-4-oxo-oxetan-2-yl)tridecan-2-yl
2-formylamino-4-methyl-pentanoate; [(2S)-1-[(2S,3S)-3-Hexyl-4-oxooxetan-2-yl]tridecan-2-yl]
(2S)-2-formamido-4-methylpentanoate; (-)-Tetrahydrolipstatin; Alli; N-Formyl-L-leucine
(3S,4S)-3-hexyl-4-((2S)-2-hydroxytridecyl)-2-oxetanone ester; Orlipastat;
Orlipastatum; |
|
PHYSICAL AND CHEMICAL PROPERTIES
|
| PHYSICAL
STATE |
white
to off-white crystalline powder |
| MELTING POINT |
|
| BOILING
POINT |
|
| RELATIVE DENSITY |
|
| SOLUBILITY
IN WATER |
Insoluble (soluble in chloroform and ethanol) |
| pH |
|
| VAPOR DENSITY |
|
|
REFRACTIVE
INDEX
|
|
|
NFPA
RATINGS
|
|
|
AUTOIGNITION
|
|
|
FLASH
POINT
|
|
| STABILITY |
Stable under normal conditions. |
|
GENERAL
DESCRIPTION & APPLICATIONS
|
Lipstatin, in
IUPAC [(2S,4E,7E)-1-(3-hexyl-4-oxooxetan-2-yl)trideca-4,7-dien-2-yl]
(2S)-2-formamido-3-methylpentanoate,is a irreversible inhibitor of pancreatic lipase,
an enzyme that breaks down triglycerides in the intestine.
Triglycerides are components of very low density lipoprotein
(VLDL) and chylomicrons, which play
an important role in metabolism
as energy sources and transporters of dietary fat. Without pancreatic lipase, triglycerides are prevented from being hydrolyzed into absorbable free fatty acids and are excreted
undigested. The saturated derivative of lipstatin ( tetrahydrolipstatin called
orlistat) is the stable form enough to develop into a drug which
reduce caloric intake by preventing the digestion, and therefore absorption of fats from the diet.
Orlistat is used as an anti-obesity drug which decreases calorie intake and increases energy expanditure
resulting in weight loss or control. Other types of anti-obesity drugs have
suppression of the appetite. Catecholamines acting as stimulants
are the
main compounds used for this. So, anti-obesity drugs carry severe side effects
including, life-threatening sometimes. Anti-obesity drugs are recommended only for short-term use
under medical prescription.
| Anti-obesity |
CAS
RN.
|
| Amfepramone |
90-84-6 |
| Benfluorex |
23602-78-0 |
| Butenolide
|
497-23-4 |
| Dapiclermin |
444069-80-1 |
| Diethylpropion hydrochloride |
134-80-5 |
| Dirlotapide |
481658-94-0 |
| Ibrolipim |
133208-93-2 |
| Metreleptin
|
186018-45-1 |
| N-Methyl-beta-carboline-3-carboxamide |
78538-74-6 |
| Norpseudoephedrine
|
36393-56-3 |
| Orlistat |
96829-58-2 |
| Perflubron |
423-55-2 |
| Phenmetrazine |
134-49-6 |
| Phentermine |
122-09-8 |
| Phenylpropanolamine |
14838-15-4 |
| Pyroglutamyl-histidyl-glycine
|
69275-10-1 |
| Rimonabant |
168273-06-1 |
| Satietin
|
72026-83-6 |
| Sibutramine
hydrochloride |
84485-00-7 |
| Sibutramine |
106650-56-0 |
| Talibegron hydrochloride |
178600-17-4 |
| Taranabant
|
701977-09-5 |
| Topiramate |
97240-79-4 |
| Trodusquemine |
186139-09-3 |
|
| SALES
SPECIFICATION (USP24) |
|
APPEARANCE
|
white
to off-white crystalline powder |
|
ASSAY
|
98.0%
min
|
|
HEAVY METALS |
10ppm
max
|
|
RESIDUE ON IGNITION |
0.1%
max
|
|
LOSS ON DRYING |
0.2% max |
| TRANSPORTATION |
| PACKING |
|
| HAZARD CLASS |
|
| UN
NO. |
|
| PRICE INFORMATION |
|
|
