|
GELDANAMYCIN |
| ((3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo- 17-azabicyclo (16.3.1)docosa-1(21),8,12,14,18-pentaen-10-yl) carbamate; |
|
|
| PRODUCT IDENTIFICATION |
|
|
CAS RN |
30562-34-6 |
|
EINECS RN |
|
|
FORMULA |
C29H40N2O9 |
|
MOLE WEIGHT |
560.64 |
|
|
| PHYSICAL AND CHEMICAL PROPERTIES |
|
|
PHYSICAL STATE |
yellow to orange powder |
|
MELTING POINT |
265 - 268 C |
|
BOILING POINT |
|
|
DENSITY |
|
|
SOLUBILITY IN WATER |
Insoluble (soluble in DMSO, Dichloromethane) |
|
pH |
|
|
VAPOR DENSITY |
|
|
REFRACTIVE INDEX |
|
|
FLASH POINT |
|
|
|
| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions |
|
INCOMPATIBLE MATERIALS |
Strong oxidizing agents, Strong acids, Strong bases. Exposure to moisture |
| DECOMPOSITION PRODUCTS |
Carbon oxides, Nitrogen oxides. |
| POLYMERIZATION | Has not been reported |
|
NFPA RATINGS |
Health: 1. Flammability: 0, Reactivity: 1 |
|
|
| SAFETY |
|
|
HAZARD NOTES |
Avoid contact and inhalation. Light sensitive. |
|
EYE |
|
|
SKIN |
|
|
INGESTION |
|
|
INHALATION |
|
|
CHRONIC |
|
|
|
| TRANSPORT & REGULATORY INFORMATION |
|
|
UN NO. |
|
| HAZARD CLASS |
|
| PACKING GROUP |
|
| HAZARD SYMBOL |
|
|
RISK PHRASES |
|
|
SAFETY PHRASES |
|
|
|
| EXTERNAL LINKS & GENERAL DESCRIPTION |
||||||||||||||||||||||||||||||||
Geldanamycin and derivates thereof are a family of a benzoquinone ansamycins,
antibiotics originally isolated on the basis of their weak antibiotic
activity that were subsequently shown to display potent antitumor activity.
Geldanamycin induces the degradation of proteins that are mutated in tumor
cells such as v-src, bcr-abl and p53 preferentially over their normal cellular
counterparts. This effect is mediated via HSP90. Despite its potent antitumor
potential, Geldanamycin has several major disadvantages as a drug candidate that
have led to the development of Geldanamycin analogues, in particular analogues
containing a substitution on the 17 position... (source: http://geldanamycin.info/index.htm)
|
|
|
| SALES SPECIFICATION |
|
|
APPEARANCE |
yellow to orange powder |
|
PURITY |
98.0% min |
|
|
| PRICE |
 |
