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LUPININE |
| (-)-Lupinine; (1R-trans)-Octahydro-2H-quinolizine-1-methanol; Octahydroquinolizine-1-methanol; (1R,9aR)-Octahydro-2H-quinolizin-1-ylmethanol; |
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| PRODUCT IDENTIFICATION |
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CAS RN |
486-70-4 |
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EINECS RN |
207-638-0 |
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FORMULA |
C10H19NO |
|
MOLE WEIGHT |
169.27 |
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| PHYSICAL AND CHEMICAL PROPERTIES |
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PHYSICAL STATE |
yellowish crystalline |
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MELTING POINT |
68 - 70 C |
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BOILING POINT |
270 C |
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DENSITY |
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SOLUBILITY IN WATER |
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pH |
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VAPOR DENSITY |
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REFRACTIVE INDEX |
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FLASH POINT |
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| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions |
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INCOMPATIBLE MATERIALS |
Strong oxidizing agents. |
| DECOMPOSITION PRODUCTS |
Carbon oxides. nitrogen oxides, ammonia |
| POLYMERIZATION | Has not been reported |
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NFPA RATINGS |
Health: 2, Flammability: 0, Reactivity: 0 |
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| SAFETY |
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HAZARD NOTES |
Toxic by ingestion, Irritant |
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EYE |
Causes eye irritation. |
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SKIN |
May be harmful if absorbed through skin. Causes skin irritation. |
|
INGESTION |
Toxic if swallowed. |
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INHALATION |
May be harmful if inhaled. Causes respiratory tract irritation. |
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CHRONIC |
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| TRANSPORT & REGULATORY INFORMATION |
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UN NO. |
2811 |
| HAZARD CLASS |
6.1 |
| PACKING GROUP |
III |
| HAZARD SYMBOL |
T |
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RISK PHRASES |
25-36/37/38 |
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SAFETY PHRASES |
26-28-36/37-45 |
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| EXTERNAL LINKS & GENERAL INFORMATION | ||||||||||||||||||||||||||||||||||||||
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Quinolizidine and isoquinoline alkaloids are a widely distributed, heterogeneous
group of alkaloids with members of each group having known toxicity to humans
and domestic animals. Cytisine, a tricyclic quinolizidine alkaloid found in Baptisia, Cytisus, Laburnum, and Sophora species, has nicotinelike effects on the gastrointestinal (GI) tract and the central nervous system (CNS). These plants may be smoked recreationally for their stimulant effects and mild hallucinogenic properties. Mescal bean may have been used by Native American peoples for ceremonial and medicinal purposes. Sophora root is used in traditional Chinese medicine where it is known as "Ku Shen" and is used to treat dysentery, scabies, itchy rashes including eczema, skin lesions, jaundice, edema, urinary dysfunction, and vaginal discharge. Lupinus species contain sparteine, a tetracyclic quinolizidine alkaloid, and lupinine, a bicyclic quinolizidine alkaloid. Lupinus species are broadly divided into bitter lupins that contain high levels of alkaloids in their seeds, and sweet lupins that contain lower levels of alkaloids and are cultivated for human consumption. Sweet lupins do contain sparteine and lupinine and must be soaked in water to prevent toxicity following ingestion. These two alkaloids are also found in other genera.(http://emedicine.medscape.com/) Many mono- and di- quinolizidine alkaloids show pharmacological actions such as antifungal, antimicrobial, analgesic, antiulcerogenic and anticancer. They are core pharmaceutical compositions of traditional Chinese medicines.
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| SALES SPECIFICATION |
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APPEARANCE |
yellowish powder |
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ASSAY |
98.0% min |
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MELTING POINT |
68 - 70 C |
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SPECIFIC ROTATION |
-23° ~ -25° |
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| PRICE INFORMATION |
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